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Preheat your oven to 375°F (190°C). Line a baking sheet with parchment paper.
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In a skillet over medium heat, cook the ground beef until fully browned. Drain excess grease.
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Stir in the garlic powder, onion powder, salt, and pepper. Remove from heat and let cool slightly.
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Flatten each biscuit into a 4–5 inch circle.
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Spoon about 2 tablespoons of the cooked beef into the center of each dough round. Add a pinch of mozzarella and Parmesan, plus a little ketchup or burger sauce if using.
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Pull the dough edges up around the filling and pinch firmly to seal, forming a ball. Place seam-side down on the baking sheet.
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In a small bowl, mix the melted butter, parsley, and Italian seasoning. Brush the tops of each dough ball generously.
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Bake for 14–16 minutes, or until golden brown and cooked through.
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Let rest for 5 minutes before serving. Sprinkle with extra Parmesan if desired.